Market concentration, supply, quality and prices paid by local authorities in the English care home market.

We investigate the impact of exogenous local conditions which favor high market concentration on supply, price and quality in local markets for care homes for older people in England. We extend the existing literature in: (i) considering supply capacity as a market outcome alongside price and quality; (ii) taking account of the chain structure of care home supply and differences between the nursing home and residential care home sectors; (iii) using an econometric approach based on reduced form relationships that treats market concentration as a jointly determined outcome of a complex market. We find that areas susceptible to a high degree of market concentration tend to have greatly restricted supply of care home places and (to a lesser extent) a higher average public cost, than areas susceptible to low degree of market concentration. There is no significant evidence that conditions favoring high market concentration affect average care home quality

The Beagle 2 optical microscope

Introduction to the Beagle2 optical microscope

The Beagle 2 microscope

The Beagle 2 microscope provides optical images of the Martian surface at a resolution 5x higher than any other experiment currently planned. By using a novel illumination system it images in three colors and can also detect fluorescent materials

Determination of the light curve of the Rosetta target asteroid (2867) Steins by the OSIRIS cameras onboard Rosetta

7 pp.-- Article published by EDP Sciences and available at http://www.aanda.org or http://dx.doi.org/10.1051/0004-6361:20066694.-- Table 2 is only available in electronic form at http://www.aanda.org.[Context] In 2004 asteroid (2867) Steins has been selected as a flyby target for the Rosetta mission. Determination of its spin period and the orientation of its rotation axis are essential for optimization of the flyby planning.[Aims] Measurement of the rotation period and light curve of asteroid (2867) Steins at a phase angle larger than achievable from ground based observations, providing a high quality data set to contribute to the determination of the orientation of the spin axis and of the pole direction.[Methods] On March 11, 2006, asteroid (2867) Steins was observed continuously for 24 h with the scientific camera system OSIRIS onboard Rosetta. The phase angle was 41.7 degrees, larger than the maximum phase angle of 30 degrees when Steins is observed from Earth. A total of 238 images, covering four rotation periods without interruption, were acquired.[Results] The light curve of (2867) Steins is double peaked with an amplitude of ≈0.23 mag. The rotation period is 6.052 ± 0.007 h. The continuous observations over four rotation periods exclude the possibility of period ambiguities. There is no indication of deviation from a principal axis rotation state. Assuming a slope parameter of G = 0.15, the absolute visual magnitude of Steins is 13.05 ± 0.03.The OSIRIS imaging system on board Rosetta is managed by the Max-Planck-Intitute for Solar System Research in Katlenburg-Lindau (Germany), thanks to an International collaboration between Germany, France, Italy, Spain, and Sweden. The support of the national funding agencies DLR, CNES, ASI, MEC, and SNSB is gratefully acknowledged. We acknowledge the work of the Rosetta Science Operations Centre at ESA/ESTEC and of the Rosetta Mission Operations Centre at ESA/ESOC who made these observations possible on short notation and operated the spacecraft. S.C.L. acknowledges support from the Leverhulme Trust. This research made use of JPL’s online ephemeris generator (HORIZONS).Peer reviewe

Shape modeling technique KOALA validated by ESA Rosetta at (21) Lutetia

We present a comparison of our results from ground-based observations of asteroid (21) Lutetia with imaging data acquired during the flyby of the asteroid by the ESA Rosetta mission. This flyby provided a unique opportunity to evaluate and calibrate our method of determination of size, 3-D shape, and spin of an asteroid from ground-based observations. We present our 3-D shape-modeling technique KOALA which is based on multi-dataset inversion. We compare the results we obtained with KOALA, prior to the flyby, on asteroid (21) Lutetia with the high-spatial resolution images of the asteroid taken with the OSIRIS camera on-board the ESA Rosetta spacecraft, during its encounter with Lutetia. The spin axis determined with KOALA was found to be accurate to within two degrees, while the KOALA diameter determinations were within 2% of the Rosetta-derived values. The 3-D shape of the KOALA model is also confirmed by the spectacular visual agreement between both 3-D shape models (KOALA pre- and OSIRIS post-flyby). We found a typical deviation of only 2 km at local scales between the profiles from KOALA predictions and OSIRIS images, resulting in a volume uncertainty provided by KOALA better than 10%. Radiometric techniques for the interpretation of thermal infrared data also benefit greatly from the KOALA shape model: the absolute size and geometric albedo can be derived with high accuracy, and thermal properties, for example the thermal inertia, can be determined unambiguously. We consider this to be a validation of the KOALA method. Because space exploration will remain limited to only a few objects, KOALA stands as a powerful technique to study a much larger set of small bodies using Earth-based observations.Comment: 15 pages, 8 figures, 2 tables, accepted for publication in P&S

Microscopic Views of Martian Soils and Evidence for Incipient Diagenesis

Mars landed missions returned im-ages at increasingly higher spatial resolution (Table 1). These images help to constrain the microstructure of Martian soils, i.e. the grain-by-grain association of chemistry and mineralogy with secondary properties, such as albedo, color, magnetic properties, and mor-phology (size, shape, texture). The secondary charac-teristics are controlled by mineralogical composition as well as the geo-setting (transport and weathering modes, e.g. water supply, pH, atmospheric properties, exposure to radiation, etc.). As of today this association is poorly constrained. However, it is important to un-derstand soil-forming processes on the surface of Mars. Here we analyze high-resolution images of soils re-turned by different landed missions. Eventually these images must be combined with other types of data (chemistry and mineralogy at small spatial scale) to nail down the microstructure of Martian soils

The microscope for the Beagle 2 lander on ESA's Mars Express

The microscope for the Beagle 2 lander on Mars Express will provide 4 µm per pixel images of rock and soil samples. The instrument is described and test results are presented

Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites

The malaria parasite Plasmodium falciparum exports several hundred proteins into the infected erythrocyte that are involved in cellular remodeling and severe virulence. The export mechanism involves the Plasmodium export element (PEXEL), which is a cleavage site for the parasite protease, Plasmepsin V (PMV). The PMV gene is refractory to deletion, suggesting it is essential, but definitive proof is lacking. Here, we generated a PEXEL-mimetic inhibitor that potently blocks the activity of PMV isolated from P. falciparum and Plasmodium vivax. Assessment of PMV activity in P. falciparum revealed PEXEL cleavage occurs cotranslationaly, similar to signal peptidase. Treatment of P. falciparum-infected erythrocytes with the inhibitor caused dose-dependent inhibition of PEXEL processing as well as protein export, including impaired display of the major virulence adhesin, PfEMP1, on the erythrocyte surface, and cytoadherence. The inhibitor killed parasites at the trophozoite stage and knockdown of PMV enhanced sensitivity to the inhibitor, while overexpression of PMV increased resistance. This provides the first direct evidence that PMV activity is essential for protein export in Plasmodium spp. and for parasite survival in human erythrocytes and validates PMV as an antimalarial drug target

Photometry of dust grains of comet 67P and connection with nucleus regions

Aims. Multiple pairs of high-resolution images of the dust coma of comet 67P/Churyumov-Gerasimenko have been collected by OSIRIS onboard Rosetta allowing extraction and analysis of dust grain tracks. Methods. We developed a quasi automatic method to recognize and to extract dust tracks in the Osiris images providing size, FWHM and photometric data. The dust tracks characterized by a low signal-to-noise ratio were checked manually. We performed the photometric analysis of 70 dust grain tracks observed on two different Narrow Angle Camera images in the two filters F24 and F28, centered at λ = 480.7 nm and at λ = 743.7 nm, respectively, deriving the color and the reddening of each one. We then extracted several images of the nucleus observed with the same filters and with the same phase angle to be compared with the dust grain reddening. Results. Most of the dust grain reddening is very similar to the nucleus values, confirming they come from the surface or subsurface layer. The histogram of the dust grain reddening has a secondary peak at negative values and shows some grains with values higher than the nucleus, suggesting a different composition from the surface grains. One hypothesis comes from the negative values point at the presence of hydrated minerals in the comet

The rotation state of 67P/Churyumov-Gerasimenko from approach observations with the OSIRIS cameras on Rosetta

Aims. Approach observations with the Optical, Spectroscopic, and Infrared Remote Imaging System (OSIRIS) experiment onboard Rosetta are used to determine the rotation period, the direction of the spin axis, and the state of rotation of comet 67P's nucleus. Methods. Photometric time series of 67P have been acquired by OSIRIS since the post wake-up commissioning of the payload in March 2014. Fourier analysis and convex shape inversion methods have been applied to the Rosetta data as well to the available ground-based observations. Results. Evidence is found that the rotation rate of 67P has significantly changed near the time of its 2009 perihelion passage, probably due to sublimation-induced torque. We find that the sidereal rotation periods P1 = 12.76129 ± 0.00005 h and P2 = 12.4043 ± 0.0007 h for the apparitions before and after the 2009 perihelion, respectively, provide the best fit to the observations. No signs of multiple periodicity are found in the light curves down to the noise level, which implies that the comet is presently in a simple rotation state around its axis of largest moment of inertia. We derive a prograde rotation model with spin vector J2000 ecliptic coordinates λ = 65° ± 15°, β = + 59° ± 15°, corresponding to equatorial coordinates RA = 22°, Dec = + 76°. However, we find that the mirror solution, also prograde, at λ = 275° ± 15°, β = + 50° ± 15° (or RA = 274°, Dec = + 27°), is also possible at the same confidence level, due to the intrinsic ambiguity of the photometric problem for observations performed close to the ecliptic plane